For U.S. healthcare professionals only
Mosaic picture of a Hemophilia A patient.

Hemophilia is a piece of them.

Not all of them.

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Indications and Limitation of Use: ADYNOVATE® [Antihemophilic factor (Recombinant), PEGylated] is a human antihemophilic factor indicated for use in children and adults with hemophilia A for the control and prevention of bleeding episodes. ADYNOVATE is not indicated for the treatment of von Willebrand disease.1

*In clinical trials, ADYNOVATE demonstrated the ability to help prevent bleeding episodes using a prophylaxis regimen.

ADYNOVATE has a simple, twice-weekly dosing schedule on the same 2 days each week, which can help personalize treatment so that your patients have more time to spend doing the other things that make them who they are.1
Collage of a hemophilia patient throughout different stages of his life.
ADYNOVATE® [Antihemophilic Factor (Recombinant), PEGylated] molecule including PEG attachment.

Designed to Extend FVIII
Circulation Time

ADYNOVATE is built on the ADVATE® [Antihemophilic Factor (Recombinant)] molecule, a proven treatment in hemophilia A patients. Created with PEGylation technology, ADYNOVATE was designed to stay in circulation longer than ADVATE, to provide factor coverage.†1-3

Proprietary PEGylation Technology exclusively licensed from Nektar Therapeutics.

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SELECTED IMPORTANT RISK INFORMATION

CONTRAINDICATIONS: Prior anaphylactic reaction to ADYNOVATE, to the parent molecule (ADVATE [Antihemophilic Factor (Recombinant)]), mouse or hamster protein, or excipients of ADYNOVATE (e.g. Tris, mannitol, trehalose, glutathione, and/or polysorbate 80).
See Detailed Important Risk Information below.

ADYNOVATE—a treatment that's approved in children and adults with hemophilia A1

Calendar icon - Weekly dosing happens the same days each week.

AS A 2X/WEEK
PROPHYLAXIS TREATMENT

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Fast watch icon.

AS AN ON-DEMAND
TREATMENT

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Gurney icon - ADYNOVATE® [Antihemophilic Factor (Recombinant), PEGylated]is indicated for surgical use and can be used before, during or after a procedure.

AS PERIOPERATIVE
MANAGEMENT

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ADYNOVATE is not indicated for the treatment of von Willebrand Disease.

SELECTED IMPORTANT RISK INFORMATION

WARNINGS & PRECAUTIONS

Neutralizing Antibodies: Formation of neutralizing antibodies (inhibitors) to factor VIII can occur following administration of ADYNOVATE. Monitor patients regularly for the development of factor VIII inhibitors by appropriate clinical observations and laboratory tests. Perform an assay that measures factor VIII inhibitor concentration if the plasma factor VIII level fails to increase as expected, or if bleeding is not controlled with expected dose.
See Detailed Important Risk Information below.

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