Simple, twice-weekly dosing schedule: same 2 days every week1
These are examples of what ADYNOVATE® [Antihemophilic Factor (Recombinant), PEGylated] prophylaxis could look like.
Work with your patients to find a schedule that’s right for them.
In the clinical trials, the majority of patients experienced the right dose, right from the start
*Two subjects increased their dose to 60 IU/kg due to bleeding in target joints.1
†Reported reasons for dose adjustment included FVIII trough levels <1%, increased risk of bleeding, and bleeding episodes.2
ADYNOVATE prophylaxis indicated dose1
Adjust the dose based on the patient's clinical response.
Dosing for on-demand treatment and control of bleeding episodes1
This information is provided as a guide for dosing ADYNOVATE® [Antihemophilic Factor (Recombinant), PEGylated] for the on-demand treatment and control of bleeding episodes. Maintain plasma factor VIII activity level at or above the described plasma levels (in IU per dL or % of normal).
|Type of Bleeding||Target FVIII Level(IU/dL or % of normal)||Dose*(IU/kg)||Frequency of Dosing(hours)||Duration of Therapy|
MinorEarly hemarthrosis, mild muscle bleeding, or mild oral bleeding episode
|20-40||10-20||12-24||Until the bleeding is resolved|
ModerateMuscle bleeding, moderate bleeding into the oral cavity, definite hemarthroses, and known trauma
|30-60||15-30||12-24||Until the bleeding is resolved|
MajorSignificant gastrointestinal bleeding, intracranial, intra-abdominal or intrathoracic bleeding, central nervous system bleeding, bleeding in the retropharyngeal or retroperitoneal spaces or iliopsoas sheath, fractures, head trauma
|60-100||30-50||8-24||Until the bleeding is resolved|
*Dose (IU/kg) = Desired factor VIII rise (IU/dL or % of normal) x 0.5 (IU/kg per IU/dL).
Dosing for perioperative management1
This information is provided as a guide for dosing ADYNOVATE® [Antihemophilic Factor (Recombinant), PEGylated] during surgery. Consideration should be given to maintain a factor VIII activity at or above the target range.
|Type of Surgery||FVIII Level Required(% of normal or IU/dL)||Dose(IU/kg)||Frequency of Doses(hours)||Duration of Treatment|
MinorIncluding tooth extraction
|60-100||30-50||Within one hour before surgery
Repeat after 24 hours if necessary
|Single dose or repeat as needed until bleeding is resolved|
MajorIntracranial, intra-abdominal, or intrathoracic surgery, joint replacement surgery
|80-120 (pre- and post-operative)||40-60||Within one hour before the operation to achieve 100% activity
Repeat every 8 to 24 hours (6 to 24 hours for patients <12 years of age) to maintain FVIII activity within the target range
|Until adequate wound healing|