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The personally identifiable information you provide to Shire will only be used for purposes for which you have provided it or as explained in our Privacy Policy Statement. Specifically, the contact information you provided (including but not limited to email, address, and phone number) will be used to contact you about the subjects you agreed to in the check boxes above. When you submit personally identifiable information, you consent to its disclosure and use for the above purposes. We may share your information with our partners or affiliates who facilitate the delivery of this information. If you ever decide that you do not wish to receive information from us regarding our products, programs, and services, contact us at: Shire Customer Service, 1200 Lakeside Drive, Bannockburn, IL 60015 or at 1-800-423-2090. If you have any questions, comments, concerns, or complaints about our information practices, call 1-844-229-2582, fax your inquiry to 224-940-5833, or send us mail at Shire Connect, 1200 Lakeside Drive, Bannockburn, IL 60015. This site does not seek to collect personal information from children under the age of 13 and will not retain this information if aware of its receipt. The privacy statement in its entirety can be accessed here.

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Detailed Important Risk Information
Prescribing Information (PI)
ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] Important Information

ADYNOVATE, Antihemophilic Factor (Recombinant), PEGylated, is a human antihemophilic factor indicated in children and adults with hemophilia A (congenital factor VIII deficiency) for:

  • On-demand treatment and control of bleeding episodes
  • Perioperative management
  • Routine prophylaxis to reduce the frequency of bleeding episodes

Limitation of Use

ADYNOVATE is not indicated for the treatment of von Willebrand disease.


Click here for ADYNOVATE full Prescribing Information.

ADVATE [Antihemophilic Factor (Recombinant)] Important Information

ADVATE is a recombinant antihemophilic factor indicated for use in children and adults with hemophilia A (congenital factor VIII deficiency) for:

  • Control and prevention of bleeding episodes.
  • Perioperative management.
  • Routine prophylaxis to prevent or reduce the frequency of bleeding episodes.

ADVATE is not indicated for the treatment of von Willebrand disease.


Neutralizing Antibodies
Neutralizing antibodies (inhibitors) have been reported following administration of ADVATE predominantly in previously untreated patients (PUPs) and previously minimally treated patients (MTPs). Monitor all patients for the development of factor VIII inhibitors by appropriate clinical observation and laboratory testing. If expected plasma factor VIII activity levels are not attained, or if bleeding is not controlled with an expected dose, perform an assay that measures factor VIII inhibitor concentration.

Click here for ADVATE full Prescribing Information.